Melatonin Attenuates PFOS‐Induced Reproductive Toxicity of Pregnant Mice due to Placental Damage Via Antioxidant, Anti‐Aging and Anti‐Inflammatory Pathways
Jianqiu Han, Zhikai Lu, Yalei Qi, Tengfei Liu, Yongmei Li, Honghui Han, Chen Zhao, Xueyun Ma · 2024
Read Melatonin Attenuates PFOS‐Induced Reproductive Toxicity of Pregnant Mice due to Placental Damage Via Antioxidant, Anti‐Aging and Anti‐Inflammatory Pathways by Jianqiu Han, Zhikai Lu, Yalei Qi, Tengfei Liu, Yongmei Li, Honghui Han, Chen Zhao, Xueyun Ma (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11635750.txt.
Description
PFOS is a long-lived industrial chemical tied to birth defects, and the placenta takes much of the hit. Jianqiu Han and seven co-authors test whether melatonin, the sleep hormone, can shield pregnancy from it in this 2024 mouse study. Pregnant mice received the chemical, the hormone, or both, and the team tracked the litters and the placentas.
Melatonin reversed the worst outcomes: more fetuses implanted, fewer were resorbed, and newborn weights recovered. Inside the placenta, a marker of oxidative damage fell while a key protective enzyme rose. The hormone seems to work on three fronts at once, fighting oxidation, cell aging, and inflammation in the tissue that feeds the fetus. The results point to melatonin as a candidate guard against a pollutant that pregnant women cannot easily avoid.
Catalog record
| CREATOR | Jianqiu Han, Zhikai Lu, Yalei Qi, Tengfei Liu, Yongmei Li, Honghui Han, Chen Zhao, Xueyun Ma |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |