ARMC5 selectively degrades SCAP-free SREBF1 and is essential for fatty acid desaturation in adipocytes
Akifumi Uota, Yosuke Okuno, Atsunori Fukuhara, Shugo Sasaki, Sachiko Kobayashi, Iichiro Shimomura · 2024
Read ARMC5 selectively degrades SCAP-free SREBF1 and is essential for fatty acid desaturation in adipocytes by Akifumi Uota, Yosuke Okuno, Atsunori Fukuhara, Shugo Sasaki, Sachiko Kobayashi, Iichiro Shimomura (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11635738.txt.
Description
SREBF1 plays the central role in lipid metabolism. It has been known that full-length SREBF1 that did not associate with SCAP (SCAP-free SREBF1) is actively degraded, but its molecular mechanism and its biological meaning remain unclear. ARMC5–CUL3 complex was recently identified as E3 ubiquitin ligase of full-length SREBF.
Catalog record
| CREATOR | Akifumi Uota, Yosuke Okuno, Atsunori Fukuhara, Shugo Sasaki, Sachiko Kobayashi, Iichiro Shimomura |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |