A Modular Approach to Obtain HER2-Targeting DM1-Loaded Nanoparticles for Gastric Cancer Therapy
Hui Zhang, Lijiao Guo, Xue Li, Hongtao Liu, Zibin Zhao, Guangling Ji, Yue Huang, Xiaodong Wang · 2024
Read A Modular Approach to Obtain HER2-Targeting DM1-Loaded Nanoparticles for Gastric Cancer Therapy by Hui Zhang, Lijiao Guo, Xue Li, Hongtao Liu, Zibin Zhao, Guangling Ji, Yue Huang, Xiaodong Wang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11635515.txt.
Description
Hui Zhang and seven colleagues designed a modular nanoparticle that delivers a potent drug to HER2-positive stomach tumors. Antibody-guided nanomedicines work well but are hard to prepare and store. The team assembled their particle from interchangeable parts. A polymer carrier was linked to the chemotherapy drug DM1 through a click reaction. The HER2 antibody trastuzumab was then attached to aim the particle. The twenty twenty-four study tested the construct in cells and mice.
The particles carried a high drug load and stayed stable in size. They killed HER2-positive gastric cancer cells at very low concentration. In mice, tumor accumulation ran six times higher than with a non-targeted version. Tumors shrank by about ninety-one percent without obvious liver or kidney harm. The modular route promises ready-to-use targeted drugs.
Catalog record
| CREATOR | Hui Zhang, Lijiao Guo, Xue Li, Hongtao Liu, Zibin Zhao, Guangling Ji, Yue Huang, Xiaodong Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |