Mapping the Binding Hotspots and Transient Binding Pockets on V-Domain Immunoglobulin Suppressor of T Cell Activation Protein Surface
Bingjie Li, Lixiu Xu, Chu Chen, Jiqing Ye · 2024
Read Mapping the Binding Hotspots and Transient Binding Pockets on V-Domain Immunoglobulin Suppressor of T Cell Activation Protein Surface by Bingjie Li, Lixiu Xu, Chu Chen, Jiqing Ye (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11635502.txt.
Description
Bingjie Li, Lixiu Xu, Chu Chen, and Jiqing Ye map binding hot spots on a protein called VISTA in a 2024 study. VISTA brakes T cells, and it sits on both immune and tumor cells, which makes it a prized drug target. Its partner protein quiets T cell growth, but the grip points between them were not known.
The team built models of the pair, ran motion simulations, and tested each grip point by swapping in a spare amino acid. Eleven points on VISTA carried most of the binding force, grouped in two zones. Tools also found fleeting pockets in those zones that scored well as drug sites.
Catalog record
| CREATOR | Bingjie Li, Lixiu Xu, Chu Chen, Jiqing Ye |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |