Microenvironmental acidification by pneumococcal sugar consumption fosters barrier disruption and immune suppression in the human alveolus
Diana Fatykhova, Verena N. Fritsch, Keerthana Siebert, Karen Methling, Michael Lalk, Tobias Busche, Jörn Kalinowski, January Weiner, Dieter Beule, Wilhelm Bertrams, Thomas P. Kohler, Sven Hammerschmidt, Anna Löwa, Mara Fischer, Maren Mieth, Katharina Hellwig, Doris Frey, Jens Neudecker, Jens C. Ruec · 2024
Read Microenvironmental acidification by pneumococcal sugar consumption fosters barrier disruption and immune suppression in the human alveolus by Diana Fatykhova, Verena N. Fritsch, Keerthana Siebert, Karen Methling, Michael Lalk, Tobias Busche, Jörn Kalinowski, January Weiner, Dieter Beule, Wilhelm Bertrams, Thomas P. Kohler, Sven Hammerschmidt, Anna Löwa, Mara Fischer, Maren Mieth, Katharina Hellwig, Doris Frey, Jens Neudecker, Jens C. Ruec (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11635383.txt.
Description
Diana Fatykhova and co-authors show how pneumococcus bacteria acidify their surroundings to damage the lung in a 2024 paper. This bacterium is the most common cause of community-acquired pneumonia worldwide. A key way it worsens disease is by breaking the barrier between air sacs and blood vessels in the lung.
The team found that when the bacteria consume sugar, they acidify the tiny environment around them. That acid fosters barrier disruption and suppresses immune defenses in the human alveolus. A metabolic side effect thus becomes a weapon, and blocking acidification could become a new angle for pneumonia treatment.
Catalog record
| CREATOR | Diana Fatykhova, Verena N. Fritsch, Keerthana Siebert, Karen Methling, Michael Lalk, Tobias Busche, Jörn Kalinowski, January Weiner, Dieter Beule, Wilhelm Bertrams, Thomas P. Kohler, Sven Hammerschmidt, Anna Löwa, Mara Fischer, Maren Mieth, Katharina Hellwig, Doris Frey, Jens Neudecker, Jens C. Ruec |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |