Mechanisms governing bystander activation of T cells
Mohammed Yosri, Mohamed Dokhan, Elizabeth Aboagye, Mouhamad Al Moussawy, Hossam A. Abdelsamed · 2024
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Description
Mohammed Yosri and co-authors review in 2024 how T cells can switch on without meeting their own target, a process called bystander activation. The immune system learns to tell self from foreign, and a real infection floods the body with signal molecules. Those signals can wake T cells that were never aimed at the infecting germ.
This waking depends mainly on those soluble signals, yet for some T cell types it may also involve the target presenting machinery. The review gathers what is known about both routes and weighs why the process matters across many settings. Named settings include infections, cancer, self directed and transplant immunity, and lasting inflammatory diseases such as artery hardening. Bystander activation can help clear threats, but it can also drive tissue harm when the target is the body's own.
Catalog record
| CREATOR | Mohammed Yosri, Mohamed Dokhan, Elizabeth Aboagye, Mouhamad Al Moussawy, Hossam A. Abdelsamed |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |