The dynamic triage interplay of Hsp90 with its chaperone cycle and client binding

Xiaozhan Qu, Simin Wang, Shuo Zhao, Chanjuan Wan, Weiya Xu, Chengdong Huang · 2024

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Description

Xiaozhan Qu and co-authors watch a cell's care crew work its rounds in a 2024 study. The crew chief in view ferries weak parts to their posts, and its dance of shape shifts drives that work, yet the steps were a blur.

A hum scan that reads atoms in broth caught the dance live in a germ's form of the chief. Fuel bits took hold and the shape swung by slow swaps from sprawl to shut. Burn of the fuel then packed the form tight. A guest part's grip threw a switch that primed the chief for hard work. The authors give a frame-by-frame read of how shape, fuel, and guest steer the crew chief's round.

Catalog record

CREATORXiaozhan Qu, Simin Wang, Shuo Zhao, Chanjuan Wan, Weiya Xu, Chengdong Huang
YEAR2024
COLLECTIONPAPERS
FORMATTXT
FILE SIZE61 KB
VERSION1.0
LICENSECC BY 4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/articles/PMC11634960

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