Cefazolin shifts the kidney microbiota to promote a lithogenic environment
Jose Agudelo, Xing Chen, Sromona D Mukherjee, Jane K Nguyen, Leslie A Bruggeman, Aaron W Miller · 2024
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Description
Jose Agudelo and co-authors report in 2024 direct evidence that kidneys hold their own microbes, and that a common surgical antibiotic shifts them. Past signs of kidney bacteria came from indirect sources. In mice, the team found bacteria in small niches inside kidney tubules, then gave an antibiotic used around surgery and watched the mix change.
Helpful lactobacillus types fell, while a family that includes many urinary pathogens grew. The effect depended on how long treatment lasted and reversed after it stopped. Two microbe types also pushed kidney stone crystal growth in opposite ways. Human kidney samples showed distinct microbe signs in two zones, with age related patterns.
Catalog record
| CREATOR | Jose Agudelo, Xing Chen, Sromona D Mukherjee, Jane K Nguyen, Leslie A Bruggeman, Aaron W Miller |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 84 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |