Nonspecific increase of αβTCR+ double-negative T cells in pediatric rheumatic diseases
Kuanysh Dossybayeva, Gulsamal Zhubanova, Assel Mussayeva, Zaure Mukusheva, Aiken Dildabayeva, Galiya Nauryzbayeva, Lyudmila Akhmaltdinova, Ulbolsyn Orumbayeva, Matthew Tanko, Dimitri Poddighe · 2024
Read Nonspecific increase of αβTCR+ double-negative T cells in pediatric rheumatic diseases by Kuanysh Dossybayeva, Gulsamal Zhubanova, Assel Mussayeva, Zaure Mukusheva, Aiken Dildabayeva, Galiya Nauryzbayeva, Lyudmila Akhmaltdinova, Ulbolsyn Orumbayeva, Matthew Tanko, Dimitri Poddighe (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11634929.txt.
Description
Dossybayeva and co-authors measure in 2024 a rare T cell type in children with rheumatic diseases. A rise in these double negative cells is one sign of a rare immune syndrome and appears in a mouse lupus model. Their place in childhood rheumatic disease was little studied.
Blood tests on patients and healthy controls used flow cytometry. Total double negative counts did not differ, but the alpha beta form ran higher in patients across all diseases studied. The gamma delta form stayed alike. Counts did not track with disease activity. The rise thus looks like a broad trait of pediatric rheumatic disease, not a sign of one diagnosis.
Catalog record
| CREATOR | Kuanysh Dossybayeva, Gulsamal Zhubanova, Assel Mussayeva, Zaure Mukusheva, Aiken Dildabayeva, Galiya Nauryzbayeva, Lyudmila Akhmaltdinova, Ulbolsyn Orumbayeva, Matthew Tanko, Dimitri Poddighe |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |