Genetic and pharmacological targeting of mTORC1 in mouse models of arteriovenous malformation expose non-cell autonomous signalling in HHT
Antonio Queiro-Palou, Yi Jin, Lars Jakobsson · 2024
Read Genetic and pharmacological targeting of mTORC1 in mouse models of arteriovenous malformation expose non-cell autonomous signalling in HHT by Antonio Queiro-Palou, Yi Jin, Lars Jakobsson (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11634917.txt.
Description
Antonio Queiro-Palou, Yi Jin, and Lars Jakobsson study, in a 2024 paper, a growth signal's role in a vessel flaw that runs in families. The flaw links arteries straight to veins in fast shunts that strain the heart. The gene flaw behind one form cuts a vessel receptor for a bone growth signal. In mouse models of that flaw, the team found a signal hub, mTORC1, switched on in retinal vessels. They asked if that hub drives the shunts, and in which cells.
Gene and drug tests split the answer. The hub's rise came after the gene flaw and was in large part a side effect of the shunts. Shutting it in vessel cells alone gave weak gains. Full block by the drug rapamycin gave the strongest gain of all. That hints that cells past the vessel wall help drive the flaw.
Catalog record
| CREATOR | Antonio Queiro-Palou, Yi Jin, Lars Jakobsson |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |