Identification of Cuproptosis‐Related Patterns Predict Prognosis and Immunotherapy Response in Hepatocellular Carcinoma
Kai Guo, Tianbing Wang, Jimin Yin, Shoushan Yang, Haodong Cui, Zichuan Cao, Qiang Zhao, Gongbo Xie, Jian Lu, Guosheng Gu, Wenyong Wu · 2024
Read Identification of Cuproptosis‐Related Patterns Predict Prognosis and Immunotherapy Response in Hepatocellular Carcinoma by Kai Guo, Tianbing Wang, Jimin Yin, Shoushan Yang, Haodong Cui, Zichuan Cao, Qiang Zhao, Gongbo Xie, Jian Lu, Guosheng Gu, Wenyong Wu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11634814.txt.
Description
Kai Guo and co-authors build a cuproptosis score to predict outlook and therapy response in liver cancer in a 2024 study. Cuproptosis is a newly found cell death mode driven by copper, and its links to cancer care were unmapped.
The score rests on nineteen related genes and splits close to five hundred tumor samples into high and low groups. Groups differed in survival, immune cell mix, drug sensitivity, and likely response to immune therapy. Network analysis flagged one key gene, glutaminase, which runs high in liver tumors and marks worse outlook. Cutting that gene slowed tumor cell growth, spread, and invasion in lab tests. The score offers a new guide for care choices.
Catalog record
| CREATOR | Kai Guo, Tianbing Wang, Jimin Yin, Shoushan Yang, Haodong Cui, Zichuan Cao, Qiang Zhao, Gongbo Xie, Jian Lu, Guosheng Gu, Wenyong Wu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |