Pharmacological blocking of neutrophil extracellular traps attenuates immunothrombosis and neuroinflammation in cerebral cavernous malformation
Favour C Onyeogaziri, Ross Smith, Maximiliano Arce, Hua Huang, Iza Erzar, Charlotte Rorsman, Matteo Malinverno, Fabrizio Orsenigo, Veronica Sundell, Dinesh Fernando, Geoffrey Daniel, Mika Niemelä, Aki Laakso, Behnam Rezai Jahromi, Anna-Karin Olsson, Peetra U Magnusson · 2024
Read Pharmacological blocking of neutrophil extracellular traps attenuates immunothrombosis and neuroinflammation in cerebral cavernous malformation by Favour C Onyeogaziri, Ross Smith, Maximiliano Arce, Hua Huang, Iza Erzar, Charlotte Rorsman, Matteo Malinverno, Fabrizio Orsenigo, Veronica Sundell, Dinesh Fernando, Geoffrey Daniel, Mika Niemelä, Aki Laakso, Behnam Rezai Jahromi, Anna-Karin Olsson, Peetra U Magnusson (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11634782.txt.
Description
Favour Onyeogaziri and a large team published a neurovascular study in twenty twenty-four on cerebral cavernous malformation, a brain vessel disorder causing strokes and bleeding. Surgery is the only current treatment. The team tested whether blocking neutrophil extracellular traps, webs of DNA that white cells cast out, could calm the disease in models.
The drug Cl-amidine, which stops traps forming, reduced lesion burden and clotting in the malformed vessels. It also quieted a damaging shift in vessel lining cells. Traps were shown to stir microglia and fibroblasts, feeding inflammation and a chronic wound-like state. Blocking them left vessels calmer and the tissue environment healthier. The authors propose trap inhibition as a drug strategy.
Catalog record
| CREATOR | Favour C Onyeogaziri, Ross Smith, Maximiliano Arce, Hua Huang, Iza Erzar, Charlotte Rorsman, Matteo Malinverno, Fabrizio Orsenigo, Veronica Sundell, Dinesh Fernando, Geoffrey Daniel, Mika Niemelä, Aki Laakso, Behnam Rezai Jahromi, Anna-Karin Olsson, Peetra U Magnusson |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 87 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |