Adipose tissue retains an epigenetic memory of obesity after weight loss
Laura C Hinte, Daniel Castellano-Castillo, Adhideb Ghosh, Kate Melrose, Emanuel Gasser, Falko Noé, Lucas Massier, Hua Dong, Wenfei Sun, Anne Hoffmann, Christian Wolfrum, Mikael Rydén, Niklas Mejhert, Matthias Blüher, Ferdinand von Meyenn · 2024
Read Adipose tissue retains an epigenetic memory of obesity after weight loss by Laura C Hinte, Daniel Castellano-Castillo, Adhideb Ghosh, Kate Melrose, Emanuel Gasser, Falko Noé, Lucas Massier, Hua Dong, Wenfei Sun, Anne Hoffmann, Christian Wolfrum, Mikael Rydén, Niklas Mejhert, Matthias Blüher, Ferdinand von Meyenn (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11634781.txt.
Description
A fifteen-author team shows that fat tissue remembers obesity long after the weight is gone. Losing weight improves health, yet keeping it off is famously hard, as if the body defends its old size. Reading single nuclei in fat from humans and mice, the team found that gene activity patterns from the obese state persist after major weight loss. In mouse fat cells, the deeper chemical marks on the genome, the epigenome, also stayed altered.
Those lingering marks blunt the cells' function and their response to food signals. Mice carrying the memory regained weight faster when the rich diet returned, and the marks predicted which genes would misbehave next. The authors name this an obesogenic memory and blame it for the yo-yo pattern of dieting. They suggest erasing the marks as a future treatment angle.
Catalog record
| CREATOR | Laura C Hinte, Daniel Castellano-Castillo, Adhideb Ghosh, Kate Melrose, Emanuel Gasser, Falko Noé, Lucas Massier, Hua Dong, Wenfei Sun, Anne Hoffmann, Christian Wolfrum, Mikael Rydén, Niklas Mejhert, Matthias Blüher, Ferdinand von Meyenn |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 92 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |