Three-dimensional adipose-derived stem cell spheroids enhance adipogenesis and angiogenesis in fat grafts: experimental research
Sang-Oh Lee, Bo-Yoon Park, Tiep Tien Nguyen, Kyoo-Ri Kwon, Mi-Jin Kim, Hae Young Yang, Jay Kim, Jee-Heon Jeong, Il-Kug Kim · 2024
Read Three-dimensional adipose-derived stem cell spheroids enhance adipogenesis and angiogenesis in fat grafts: experimental research by Sang-Oh Lee, Bo-Yoon Park, Tiep Tien Nguyen, Kyoo-Ri Kwon, Mi-Jin Kim, Hae Young Yang, Jay Kim, Jee-Heon Jeong, Il-Kug Kim (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11634189.txt.
Description
Moving a patient's own fat to rebuild tissue works better when stem cells from fat are mixed in, and growing those cells as three-dimensional balls may help them thrive. Sang-Oh Lee and eight co-authors compare ball-grown stem cells with flat-grown ones, in dishes and in fat grafts. The work is reported as a research letter with full methods in a supplement.
In the lab, the ball-grown cells formed fat and blood vessels more readily, resisted low oxygen better, and showed lower inflammation markers. In grafts, they survived and blended in better, with denser blood vessel growth. Gene analysis matched the picture: pathways for fat and vessel growth rose, while those for inflammation, oxygen shortage, and scarring fell. The authors say the results rest on direct gene evidence, not just protein measures, in 2024.
Catalog record
| CREATOR | Sang-Oh Lee, Bo-Yoon Park, Tiep Tien Nguyen, Kyoo-Ri Kwon, Mi-Jin Kim, Hae Young Yang, Jay Kim, Jee-Heon Jeong, Il-Kug Kim |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 16 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |