Development of a spontaneous model of renal interstitial fibrosis in NOD/SCID mice: Aging-induced pathogenesis
Lihua Qiu, Zhaoxia Ma, Jinyan Li, Zhen Wu, Longmei Dai, Ruimin Long, Linlin Hu, Jianxiu Sun, Min Hu, Yanjiao Li · 2024
Read Development of a spontaneous model of renal interstitial fibrosis in NOD/SCID mice: Aging-induced pathogenesis by Lihua Qiu, Zhaoxia Ma, Jinyan Li, Zhen Wu, Longmei Dai, Ruimin Long, Linlin Hu, Jianxiu Sun, Min Hu, Yanjiao Li (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11633998.txt.
Description
Qiu and colleagues published in twenty twenty-four a mouse study creating a natural aging model of kidney scarring. Kidney interstitial fibrosis builds with age and leads toward kidney failure. Models that mimic natural aging are needed to test anti-scarring drugs. Immune-deficient mice also let delivered human cells survive for therapy tests. The team compared kidneys of mice at twelve, thirty-two, and forty-three weeks. The oldest group showed clear fibrosis with collagen build-up and fibrous bands.
Aging markers confirmed cell senescence in the model kidneys. A key scarring pathway switched on, matched by mitochondrial trouble and oxidative stress. Inflammation rose as antioxidant defenses fell in the tissue. The pattern mirrors kidney fibrosis in elderly humans closely. The authors present the model as a platform for mechanism work. It should also suit tests of cell therapies for aged kidneys.
Catalog record
| CREATOR | Lihua Qiu, Zhaoxia Ma, Jinyan Li, Zhen Wu, Longmei Dai, Ruimin Long, Linlin Hu, Jianxiu Sun, Min Hu, Yanjiao Li |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |