Investigation of the inhibitory properties of azo-dyes on chorismate synthase from Paracoccidioides brasiliensis
Katharina Fuchs, Massimo G Totaro, Marina Toplak, Aleksandar Bijelic, Peter Macheroux · 2024
Read Investigation of the inhibitory properties of azo-dyes on chorismate synthase from Paracoccidioides brasiliensis by Katharina Fuchs, Massimo G Totaro, Marina Toplak, Aleksandar Bijelic, Peter Macheroux (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11633415.txt.
Description
Katharina Fuchs and co-authors test bright azo dyes as blockers of a fungus enzyme that could be a drug target. The enzyme, chorismate synthase, ends the shikimate path that fungi need and people lack. Their 2024 study screens dyes against the enzyme from Paracoccidioides brasiliensis, a fungus that infects lungs. One dye, PH011669, bound tightly and shut the enzyme down at low doses.
Computer docking and motion simulations showed how the dye sits in the active site. Electric pulls do most of the holding. The work is a first: it blends structure and computing to guide chorismate synthase blockers. Stronger kin of this dye could seed new antifungal drugs.
Catalog record
| CREATOR | Katharina Fuchs, Massimo G Totaro, Marina Toplak, Aleksandar Bijelic, Peter Macheroux |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |