Changes in immunofluorescence staining during islet regeneration in a cystic fibrosis-related diabetes (CFRD) ferret model
Sawash M. Mohammed, Robert N. Bone, Jacqueline Del Carmen Aquino, Raghavendra G. Mirmira, Carmella Evans-Molina, Heba M. Ismail · 2024
Read Changes in immunofluorescence staining during islet regeneration in a cystic fibrosis-related diabetes (CFRD) ferret model by Sawash M. Mohammed, Robert N. Bone, Jacqueline Del Carmen Aquino, Raghavendra G. Mirmira, Carmella Evans-Molina, Heba M. Ismail (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11633224.txt.
Description
Sawash Mohammed and co-authors tracked hormone patterns in the pancreas of ferrets bred to model cystic fibrosis, in a 2024 study. In these animals, blood sugar swings through set phases before diabetes linked to the disease sets in. First comes a month of normal sugar, then two months of high sugar with loss of hormone-making cell clusters. A calmer phase follows, in which those clusters grow back.
The team stained the clusters to see how three signals changed across the phases. Insulin staining ran high in the first phase, then fell below normal in the third. A second hormone moved the other way, while a precursor form fell across the later phases. Ratios between the signals also flipped between phases. The authors read the shifts as a map of how the disease reshapes the pancreas before diabetes takes hold.
Catalog record
| CREATOR | Sawash M. Mohammed, Robert N. Bone, Jacqueline Del Carmen Aquino, Raghavendra G. Mirmira, Carmella Evans-Molina, Heba M. Ismail |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |