Signatures of Six Autophagy‐Related Genes as Diagnostic Markers of Thyroid‐Associated Ophthalmopathy and Their Correlation With Immune Infiltration
Qintao Ma, Yuanping Hai, Jie Shen · 2024
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Description
Qintao Ma, Hai, and Shen hunt gene markers for thyroid-associated eye disease, a tangled autoimmune illness that bulges and inflames the eyes. Their angle is autophagy, the cell's recycling system. Comparing patients and controls, they found twenty-four such genes behaving differently, then let three selection methods compete to shrink the list to a diagnostic few.
Six genes survived all three screens and held up in a separate dataset. Together they split patients from controls with a score of 0.948, and a points chart built on them did better still. Each gene also tracked the mix of immune cells in tissue, hinting the set reflects the disease's immune invasion, not just its shadow.
Catalog record
| CREATOR | Qintao Ma, Yuanping Hai, Jie Shen |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |