The Role of Fibrinogen in Mediating NGAL-Associated Neuronal Damage in Acute Ischemic Stroke: A Moderated Mediation Analysis
Nan Zhao, Yi Chen, Zhongjiao Lu, Lu Han, Yaying Song, Jie Ding, Desheng Zhu, Yangtai Guan · 2024
Read The Role of Fibrinogen in Mediating NGAL-Associated Neuronal Damage in Acute Ischemic Stroke: A Moderated Mediation Analysis by Nan Zhao, Yi Chen, Zhongjiao Lu, Lu Han, Yaying Song, Jie Ding, Desheng Zhu, Yangtai Guan (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11632793.txt.
Description
Nan Zhao and seven co-authors probe how two inflammation-linked proteins relate to brain cell damage after a blood-flow stroke. One protein, NGAL, rises with inflammation; the other, fibrinogen, helps blood clot and also feeds inflammation. The team studied one hundred ninety-six stroke patients at a hospital in China, measuring both proteins plus a marker that signals neuron damage.
All three measures rose together in straight-line fashion. Statistical modeling suggested that about fourteen percent of the link between the first protein and neuron damage runs through fibrinogen. In other words, part of NGAL's association with harm may act by way of the clotting protein. Splitting patients into subgroups did not change the pattern. The authors say calming this inflammatory chain might limit brain damage after stroke. They call for animal studies to pin down the exact mechanism.
Catalog record
| CREATOR | Nan Zhao, Yi Chen, Zhongjiao Lu, Lu Han, Yaying Song, Jie Ding, Desheng Zhu, Yangtai Guan |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |