Genetically Engineered Liposwitch-Based Nanomaterials
Md Shahadat Hossain, Alex Wang, Salma Anika, Zhe Zhang, Davoud Mozhdehi · 2024
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Description
Shahadat Hossain and four co-authors create nanomaterials whose assembly can be switched by a lipid tag that hides or shows itself. Their paper came out in 2024. Proteins are attractive building blocks for nanomaterials, but once a protein is made, its structure is normally fixed and cannot adapt.
They fused a calcium-sensitive switch protein to a stretchy, heat-responsive protein chain. When calcium arrives, the switch exposes its fatty tag, which seeks out membranes and changes how the fusion protein clumps. Light scattering and electron microscopy confirmed that assembly depended on both calcium and the lipid tag being present. The authors call this strategy liposwitching. They propose it for synthetic biology and cell engineering, where controllable assembly is valuable.
Catalog record
| CREATOR | Md Shahadat Hossain, Alex Wang, Salma Anika, Zhe Zhang, Davoud Mozhdehi |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |