Evaluating the impact of LHCGR gene polymorphism on polycystic ovary syndrome: a comprehensive meta-analysis and power assessment
Sheena Mariam Thomas, Ramakrishnan Veerabathiran · 2024
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Description
Sheena Mariam Thomas and Ramakrishnan Veerabathiran pool the evidence on one gene variant and polycystic ovary syndrome, in a study published in 2024. The syndrome affects about 3.6 percent of women worldwide, disturbing hormones, cycles, and fertility. The LHCGR gene, which builds the receptor for two reproductive hormones, is a natural suspect, and one variant, rs2293275, has been tested in many small studies.
The meta-analysis gathered ten case-control studies with 1,431 patients and 1,317 controls across ethnic groups and genetic models, and added a formal power assessment. The headline result, cut off in the summary available here, reports no significant overall association. Pooling with power analysis helps settle whether a much-studied variant is a real risk factor or a literature mirage.
Catalog record
| CREATOR | Sheena Mariam Thomas, Ramakrishnan Veerabathiran |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |