EGFR-V834L combined with L858R mutation reduced afatinib sensitivity and associated to early recurrence in lung cancer
Nanao Terada, Hayato Koba, Shigeki Nanjo, Hideharu Kimura, Akihiro Nishiyama, Taro Yoneda, Takayuki Takeda, Hiroki Shirasaki, Koichi Nishi, Takashi Sone, Tadaaki Yamada, Koichi Takayama, Kazuhiko Shibata, Hiroki Matsuoka, Toshiyuki Kita, Kazuhiro Nagata, Yuichi Tambo, Noriyuki Ohkura, Johsuke Hara, · 2024
Read EGFR-V834L combined with L858R mutation reduced afatinib sensitivity and associated to early recurrence in lung cancer by Nanao Terada, Hayato Koba, Shigeki Nanjo, Hideharu Kimura, Akihiro Nishiyama, Taro Yoneda, Takayuki Takeda, Hiroki Shirasaki, Koichi Nishi, Takashi Sone, Tadaaki Yamada, Koichi Takayama, Kazuhiko Shibata, Hiroki Matsuoka, Toshiyuki Kita, Kazuhiro Nagata, Yuichi Tambo, Noriyuki Ohkura, Johsuke Hara, (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11632430.txt.
Description
Nanao Terada and co-authors analyzed blood-borne DNA in 2024 to find which gene changes blunt a second-line lung cancer drug. The patients carried a mutated growth receptor, EGFR, and were treated with afatinib after the front-line drug class met resistance. Cell-free DNA, shed by tumors into the blood, let the team watch the cancer's genes without a biopsy.
In a prospective multi-center trial, the analysis tied one double mutation, V834L riding beside the common L858R change, to weaker response and early relapse, as the title states. The byline is a long team list, framed here by its lead author. Readers get a blood-test warning sign for oncologists: a rare passenger mutation that forecasts a short run on a fallback drug.
Catalog record
| CREATOR | Nanao Terada, Hayato Koba, Shigeki Nanjo, Hideharu Kimura, Akihiro Nishiyama, Taro Yoneda, Takayuki Takeda, Hiroki Shirasaki, Koichi Nishi, Takashi Sone, Tadaaki Yamada, Koichi Takayama, Kazuhiko Shibata, Hiroki Matsuoka, Toshiyuki Kita, Kazuhiro Nagata, Yuichi Tambo, Noriyuki Ohkura, Johsuke Hara, |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |