Multi-omics analysis reveals indicator features of microbe-host interactions during Candida albicans colonization and subsequent infection
Huan Zhang, Daoyuan Song, Qiulin Luo, Jiangkun Yu, Yingpu Wei, Di Chen, Guangjuan Wu, Zhi Zhang, Zhao Li, Hongchao Jiang, Jingquan Gan, Deyao Deng, Hui Li, Wenli Yuan · 2024
Read Multi-omics analysis reveals indicator features of microbe-host interactions during Candida albicans colonization and subsequent infection by Huan Zhang, Daoyuan Song, Qiulin Luo, Jiangkun Yu, Yingpu Wei, Di Chen, Guangjuan Wu, Zhi Zhang, Zhao Li, Hongchao Jiang, Jingquan Gan, Deyao Deng, Hui Li, Wenli Yuan (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11632224.txt.
Description
Huan Zhang and co-authors trace how a common yeast moves from gut colonization to bloodstream infection, in a 2024 study. The yeast, Candida albicans, lives quietly in many guts but can turn invasive in hospital patients. The study began with thirty-one patients who had Candida bloodstream infections at a Chinese university hospital. Risk factors for gut colonization were weighed first.
Animal models then reproduced the path from gut settlement to kidney infection. Gene, microbe, and metabolite scans of the colon showed a clear pattern as disease advanced. A brake on immune cells, called PD-1, fell in colon tissue. Helpful gut bacteria and their fatty acid products dropped, while other microbes and compounds rose. The authors say these shifts could serve as warning signs of infection to come.
Catalog record
| CREATOR | Huan Zhang, Daoyuan Song, Qiulin Luo, Jiangkun Yu, Yingpu Wei, Di Chen, Guangjuan Wu, Zhi Zhang, Zhao Li, Hongchao Jiang, Jingquan Gan, Deyao Deng, Hui Li, Wenli Yuan |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |