Role of eosinophil counts in mediating the association between asthma and colon cancer
Zhi‐Qing Zhan, Ze‐Min Huang, Zhi‐Xin Xie, Hao‐Bin Zhou, Yu‐Hua Luo, Pei‐Zhen Chen, Tian‐Ye Luo, Baoqing Sun, Zhangkai J Cheng · 2024
Read Role of eosinophil counts in mediating the association between asthma and colon cancer by Zhi‐Qing Zhan, Ze‐Min Huang, Zhi‐Xin Xie, Hao‐Bin Zhou, Yu‐Hua Luo, Pei‐Zhen Chen, Tian‐Ye Luo, Baoqing Sun, Zhangkai J Cheng (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11632118.txt.
Description
Zhi-Qing Zhan and eight co-authors published a 2024 study asking whether asthma changes the risk of colon cancer, and whether a white blood cell type carries the effect. Past population studies gave mixed answers on the asthma and cancer link. The team used genetics to test cause rather than mere correlation.
Their method, Mendelian randomization, uses gene variants as natural experiments. The analysis suggested that asthma lowers colon cancer risk, and that eosinophil counts, a cell type high in asthma, mediate part of that effect. Extra checks supported the finding. Gene analyses then flagged a protein, PPP1R14A, as a possible treatment target tied to eosinophils. More of that protein may mark a better outlook for colon cancer patients.
Catalog record
| CREATOR | Zhi‐Qing Zhan, Ze‐Min Huang, Zhi‐Xin Xie, Hao‐Bin Zhou, Yu‐Hua Luo, Pei‐Zhen Chen, Tian‐Ye Luo, Baoqing Sun, Zhangkai J Cheng |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |