Coelimycin inside out — negative feedback regulation by its intracellular precursors
Magdalena Kotowska, Mateusz Wenecki, Bartosz Bednarz, Jarosław Ciekot, Wojciech Pasławski, Tomasz Buhl, Krzysztof J. Pawlik · 2024
Read Coelimycin inside out — negative feedback regulation by its intracellular precursors by Magdalena Kotowska, Mateusz Wenecki, Bartosz Bednarz, Jarosław Ciekot, Wojciech Pasławski, Tomasz Buhl, Krzysztof J. Pawlik (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11632069.txt.
Description
Magdalena Kotowska and six co-authors study self-regulation in an antibiotic-making bacterium in a paper from two thousand twenty-four. The bacterium produces coelimycin, a natural product whose gene cluster is tightly controlled. Products and precursors of such pathways can themselves steer the genes that make them.
Reporter tests compared gene activity in normal bacteria and two mutants: one unable to export the finished product, one unable to make it at all. Every tested promoter ran hot when no product was made, but looked normal when only export was blocked. That pattern shows the precursor inside the cell acts as the silencer of its own production. The team also proves the exporter pump is essential for releasing the product outside.
Catalog record
| CREATOR | Magdalena Kotowska, Mateusz Wenecki, Bartosz Bednarz, Jarosław Ciekot, Wojciech Pasławski, Tomasz Buhl, Krzysztof J. Pawlik |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |