Association of Lactate with Risk of Cardiovascular Diseases: A Two-Sample Mendelian Randomization Study
Xindi Chang, Wang Zheng, Yingli Zhao, Wangkang Niku, Bing Deng, Ping Liu, Yiru Wang · 2024
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Description
Xindi Chang and six co-authors used genetics to test whether lactate is linked to heart and vessel disease in a 2024 study. Lactate runs high in cardiovascular patients, and cutting its production has been floated as a treatment idea. But ordinary observation cannot separate cause from coincidence. Mendelian randomization uses gene variants as natural experiments to firm up causal claims, drawing on large genome databases.
The team examined thirteen conditions, from coronary disease and heart failure to stroke and clots. Only two showed genetic links, and in the reverse direction: inherited tendency to coronary atherosclerosis and to peripheral artery disease predicted higher lactate. No genetic evidence tied lactate itself to the other eleven conditions. The findings narrow where lactate may matter in vessel disease.
Catalog record
| CREATOR | Xindi Chang, Wang Zheng, Yingli Zhao, Wangkang Niku, Bing Deng, Ping Liu, Yiru Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |