The possible interaction between tryptophan and its metabolites with delirium in older patients with critical illnesses
Korhan Kollu, Huseyin Kurku, Ali Unlu, Busra Ecer, Ibrahim Guney, Muhammet Cemal Kizilarslanoglu · 2024
Read The possible interaction between tryptophan and its metabolites with delirium in older patients with critical illnesses by Korhan Kollu, Huseyin Kurku, Ali Unlu, Busra Ecer, Ibrahim Guney, Muhammet Cemal Kizilarslanoglu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11632029.txt.
Description
Korhan Kollu and five colleagues test whether tryptophan breakdown products can flag delirium in older patients in intensive care. The study followed 120 patients over sixty in a medical intensive care unit. In their first twenty-four hours, blood levels of tryptophan and five products made from it were compared between patients who did and did not develop delirium.
Patients with delirium were older and had higher scores for other illnesses. Their tryptophan was lower. Ratios of kynurenine and quinolinic acid to tryptophan were much higher. The kynurenine ratio was the strongest single predictor. One ratio kept a borderline link on its own in the adjusted analysis. The authors say these early blood markers could flag high-risk patients for preventive care.
Catalog record
| CREATOR | Korhan Kollu, Huseyin Kurku, Ali Unlu, Busra Ecer, Ibrahim Guney, Muhammet Cemal Kizilarslanoglu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |