Alk1/Endoglin signaling restricts vein cell size increases in response to hemodynamic cues
Zeenat Diwan, Jia Kang, Emma Tsztoo, Arndt F Siekmann · 2024
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Description
Zeenat Diwan and co-authors find that veins break the rules arteries follow when blood flow changes in a 2024 study. Vessels are thought to widen under strong flow and narrow under weak flow, holding shear stress near a set point. When that control fails, artery-vein malformations can grow.
In zebrafish embryos, arteries obeyed the set point rule but veins did not: their lining cells barely grew under higher flow. Mosaic experiments traced the restraint to two signaling proteins, Alk1 and Endoglin. Mutant vein cells swelled under normal flow, veins widened, and the extra flow then ballooned connected arteries, seeding a malformation. The mechanism explains how a few mutant vein cells can trigger a large tangle.
Catalog record
| CREATOR | Zeenat Diwan, Jia Kang, Emma Tsztoo, Arndt F Siekmann |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |