Cross-regulation of RNA methylation modifications and R-loops: from molecular mechanisms to clinical implications
Yuqing Wu, Shen Lin, Hong Chen, Xiangyi Zheng · 2024
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Description
Yuqing Wu and co-authors review how chemical marks on RNA and loop structures where RNA sticks to DNA regulate each other, in work published in 2024. Such loops help control gene activity and DNA repair, yet excess loops threaten genome stability. Two common RNA marks appear to steer loop life both ways.
The marks can help loops form, settle, or dissolve during gene reading and damage repair. When the marking system slips, loop balance breaks, a pattern tied to cancers and brain disorders. The authors map the known mechanisms and the disease links. They close with ideas for treatments that target the mark and loop interplay.
Catalog record
| CREATOR | Yuqing Wu, Shen Lin, Hong Chen, Xiangyi Zheng |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |