Genomic profiling of NSCLC tumors with the TruSight oncology 500 assay provides broad coverage of clinically actionable genomic alterations and detection of known and novel associations between genomic alterations, TMB, and PD-L1
Zachary D. Wallen, Mary K. Nesline, Marni Tierno, Alison Roos, Erica Schnettler, Hatim Husain, Pratheesh Sathyan, Brian Caveney, Marcia Eisenberg, Eric A. Severson, Shakti H. Ramkissoon · 2024
Read Genomic profiling of NSCLC tumors with the TruSight oncology 500 assay provides broad coverage of clinically actionable genomic alterations and detection of known and novel associations between genomic alterations, TMB, and PD-L1 by Zachary D. Wallen, Mary K. Nesline, Marni Tierno, Alison Roos, Erica Schnettler, Hatim Husain, Pratheesh Sathyan, Brian Caveney, Marcia Eisenberg, Eric A. Severson, Shakti H. Ramkissoon (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11631745.txt.
Description
Ten authors led by Zachary Wallen profile lung tumours from more than seven thousand patients with one broad gene test. Matching a lung cancer patient to the right targeted or immune drug is hard when tests check one mark at a time. Their assay reads hundreds of gene marks at once, plus marks that hint at immune drug response. The cohort held advanced cases of the most common lung cancer type in two cell forms.
More than 72 percent of tumours held a change with a drug or trial fit in reach. The two cell forms showed distinct gene prints of their own. Known links held, such as low mutation load next to drug-fit changes. Fresh links among gene changes and immune marks also surfaced in the sweep. One broad test thus sorts most patients in one pass.
Catalog record
| CREATOR | Zachary D. Wallen, Mary K. Nesline, Marni Tierno, Alison Roos, Erica Schnettler, Hatim Husain, Pratheesh Sathyan, Brian Caveney, Marcia Eisenberg, Eric A. Severson, Shakti H. Ramkissoon |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |