Derivation of a comprehensive semi-empirical proton RBE model from published experimental cell survival data collected in the PIDE database
Jian-Yue Jin, Jiankui Yuan, Xiaohang Qin, Yinghui Li, Huagang Yan, Nancy L. Oleinick, Min Yao, Quintin Pan, Feng-Ming (Spring) Kong, Mitchell Machtay · 2024
Read Derivation of a comprehensive semi-empirical proton RBE model from published experimental cell survival data collected in the PIDE database by Jian-Yue Jin, Jiankui Yuan, Xiaohang Qin, Yinghui Li, Huagang Yan, Nancy L. Oleinick, Min Yao, Quintin Pan, Feng-Ming (Spring) Kong, Mitchell Machtay (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11631728.txt.
Description
Jian-Yue Jin and co-authors build a model for how much more proton beams damage cells than X-rays. Their 2024 study uses cell survival data from a public database of particle experiments. Seventy two data sets across four cell lines were eligible. A classic survival model was replaced by one based on damage creation and repair rates. Those rates were tied to beam energy loss in simple linear forms.
A multi curve fit then matched all data sets at once. It yielded the rate parameters for each cell line. Values were close across lines, with averages the authors report. One parameter scaled with the X-ray damage rate. From these pieces, a general model for relative effect was derived. Such models guide dose planning in proton therapy, where the boost over X-rays must be estimated for each tissue.
Catalog record
| CREATOR | Jian-Yue Jin, Jiankui Yuan, Xiaohang Qin, Yinghui Li, Huagang Yan, Nancy L. Oleinick, Min Yao, Quintin Pan, Feng-Ming (Spring) Kong, Mitchell Machtay |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |