Defining Renal Recovery in Patients With Hepatorenal Syndrome‐Acute Kidney Injury: Experience From North American Studies
Muhammad A Mujtaba, Hussien Elsiesy, Sara Faiz, Syed A Hussain, Ann Kathleen N Gamilla‐Crudo, Aftab Karim, Mohammad Irfan Khan, Muhammad Waqar Khattak, Zunaira Zafar, Michael Kueht, Khurram Jamil · 2024
Read Defining Renal Recovery in Patients With Hepatorenal Syndrome‐Acute Kidney Injury: Experience From North American Studies by Muhammad A Mujtaba, Hussien Elsiesy, Sara Faiz, Syed A Hussain, Ann Kathleen N Gamilla‐Crudo, Aftab Karim, Mohammad Irfan Khan, Muhammad Waqar Khattak, Zunaira Zafar, Michael Kueht, Khurram Jamil (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11631707.txt.
Description
Muhammad Mujtaba and ten co-authors asked how kidney recovery should be defined in a severe liver-kidney syndrome, in a 2024 paper. Trials of the main drug use full reversal of the syndrome as their goal. A simpler yardstick is a drop of at least thirty percent in a blood marker of kidney strain. The team pooled data from three North American trials.
Patients on the drug hit the thirty percent mark far more often than those on placebo. Those who hit it needed dialysis far less by day ninety. They also survived at higher rates and kept their recovery longer. Even without full reversal, hitting the mark matched the outcomes of full reversal groups. The authors propose the thirty percent drop as a meaningful recovery endpoint. It could simplify how future trials judge success.
Catalog record
| CREATOR | Muhammad A Mujtaba, Hussien Elsiesy, Sara Faiz, Syed A Hussain, Ann Kathleen N Gamilla‐Crudo, Aftab Karim, Mohammad Irfan Khan, Muhammad Waqar Khattak, Zunaira Zafar, Michael Kueht, Khurram Jamil |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |