Causal relationship between hypothyroidism and peripheral neuropathy: a Mendelian randomization study of European ancestry
Xiping Duan, Tianchi Zhang, Ke Wang · 2024
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Description
Xiping Duan, Tianchi Zhang, and Ke Wang use gene data to ask whether an underactive thyroid causes nerve damage in the limbs. Metabolic problems are known risk factors for peripheral neuropathy, but clinic studies cannot separate cause from coincidence. Their 2024 Mendelian randomization study works with people of European ancestry.
Genetic variants tied to hypothyroidism served as stand-ins for the condition itself. The team checked eight nerve diseases as outcomes. Hypothyroidism raised the risk of diabetic nerve damage, with odds about 22 percent higher, and slightly raised risks of nerve root disorders and carpal tunnel syndrome. Oddly, it looked mildly protective against polyneuropathies as a group. Sensitivity checks supported the main pattern. Thyroid care may matter for nerve health.
Catalog record
| CREATOR | Xiping Duan, Tianchi Zhang, Ke Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |