Population pharmacokinetics and dose optimization of ceftazidime in critically ill children
Mengting Li, Liuliu Gao, Zuo Wang, Lingkong Zeng, Chen Chen, Jun Wang, Sichan Li, Maochang Liu, Yang Wang · 2024
Read Population pharmacokinetics and dose optimization of ceftazidime in critically ill children by Mengting Li, Liuliu Gao, Zuo Wang, Lingkong Zeng, Chen Chen, Jun Wang, Sichan Li, Maochang Liu, Yang Wang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11631598.txt.
Description
Mengting Li and co-authors modeled dosing of an antibiotic in critically ill children, in this 2024 study. Ceftazidime must stay above a germ-killing level for much of the day. The team built a population model from 88 children in intensive care, with 100 blood measures.
A one-compartment model fit best. Weight and kidney function drove how fast the drug cleared. Simulations set dose plans by weight and kidney group. Standard doses hit the target for germs of low to mid resistance. Tougher germs at the top level would need higher doses. The authors back tailored dosing in the unit.
Catalog record
| CREATOR | Mengting Li, Liuliu Gao, Zuo Wang, Lingkong Zeng, Chen Chen, Jun Wang, Sichan Li, Maochang Liu, Yang Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |