Anti-tumor and anti-metastatic effects of RRx-001 on hepatocellular carcinoma: mechanisms of action and therapeutic potential
Guohong Yan, Shuqi Zhao, Meifeng Chen, Shutian Mo, Hailian Huang, Yuan Liao, Ziyan Lu, Jiaming Liang, Shuxin Wei, Chuangye Han, Xinping Ye · 2024
Read Anti-tumor and anti-metastatic effects of RRx-001 on hepatocellular carcinoma: mechanisms of action and therapeutic potential by Guohong Yan, Shuqi Zhao, Meifeng Chen, Shutian Mo, Hailian Huang, Yuan Liao, Ziyan Lu, Jiaming Liang, Shuxin Wei, Chuangye Han, Xinping Ye (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11631591.txt.
Description
Guohong Yan and ten co-authors test a drug candidate against liver cancer in lab and mouse studies, in a paper from 2024. The drug had shown strong effects in other cancers, but its action in liver cancer was less clear. The team set out to map how it works and whether it can slow spread.
Treated liver cancer cells lived less, moved less, and died more as dose and time rose. Gene checks pointed to two key proteins, one falling and one rising, that steer growth signals. In mice, the drug slowed tumor growth as well. The authors see promise, but note the work is still at an early stage.
Catalog record
| CREATOR | Guohong Yan, Shuqi Zhao, Meifeng Chen, Shutian Mo, Hailian Huang, Yuan Liao, Ziyan Lu, Jiaming Liang, Shuxin Wei, Chuangye Han, Xinping Ye |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |