Etiology, histology, and long-term outcome of bilateral testicular regression: a large Belgian series
L J W Tack, C Brachet, V Beauloye, C Heinrichs, E Boros, K De Waele, S van der Straaten, S Van Aken, M Craen, A Lemay, A Rochtus, K Casteels, D Beckers, T Mouraux, K Logghe, M Van Loocke, G Massa, K Van de Vijver, H Syryn, J Van De Velde, E De Baere, H Verdin, M Cools · 2023
Read Etiology, histology, and long-term outcome of bilateral testicular regression: a large Belgian series by L J W Tack, C Brachet, V Beauloye, C Heinrichs, E Boros, K De Waele, S van der Straaten, S Van Aken, M Craen, A Lemay, A Rochtus, K Casteels, D Beckers, T Mouraux, K Logghe, M Van Loocke, G Massa, K Van de Vijver, H Syryn, J Van De Velde, E De Baere, H Verdin, M Cools (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11631441.txt.
Description
Tack and a large Belgian team follow people born with both testes regressed before birth. Their large series from twenty twenty-three examines causes and long-term outcomes. The rare condition leaves no working gonads at birth. A blood vessel accident was the classic suspected cause.
Genetic variants in one gene also explain some cases. Growth and puberty progressed well on hormone replacement. Dose increases followed a standard schedule through childhood. Penile growth often stayed below target despite treatment. That shortfall was worst with genetic causes or small size at birth. Tissue studies added detail on what remains of the gonads. Families gain realistic expectations for long-term care.
Catalog record
| CREATOR | L J W Tack, C Brachet, V Beauloye, C Heinrichs, E Boros, K De Waele, S van der Straaten, S Van Aken, M Craen, A Lemay, A Rochtus, K Casteels, D Beckers, T Mouraux, K Logghe, M Van Loocke, G Massa, K Van de Vijver, H Syryn, J Van De Velde, E De Baere, H Verdin, M Cools |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |