Amygdala-predominant α-synuclein pathology is associated with exacerbated hippocampal neuron loss in Alzheimer’s disease
Klara Gawor, Sandra O Tomé, Rik Vandenberghe, Philip Van Damme, Mathieu Vandenbulcke, Markus Otto, Christine A F von Arnim, Estifanos Ghebremedhin, Alicja Ronisz, Simona Ospitalieri, Matthew Blaschko, Dietmar Rudolf Thal · 2024
Read Amygdala-predominant α-synuclein pathology is associated with exacerbated hippocampal neuron loss in Alzheimer’s disease by Klara Gawor, Sandra O Tomé, Rik Vandenberghe, Philip Van Damme, Mathieu Vandenbulcke, Markus Otto, Christine A F von Arnim, Estifanos Ghebremedhin, Alicja Ronisz, Simona Ospitalieri, Matthew Blaschko, Dietmar Rudolf Thal (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11631359.txt.
Description
Many Alzheimer's brains also carry clumps of a second protein, alpha-synuclein, and in some patients those clumps gather mainly in the amygdala. A twelve-author team studies 291 autopsy brains in 2024 to ask what that pattern does. They grade the protein's spread across seven regions and count neurons in the hippocampus, the brain's memory hub. Among 99 patients with Alzheimer's symptoms, they also grade two companion proteins.
The amygdala-heavy pattern pairs with the steepest neuron loss in the hippocampus. Those same cases carry the worst load of the companion protein TDP-43. Path analysis ties the proteins into one web leaning on the memory hub. The authors argue the amygdala route marks a harsher branch of the disease.
Catalog record
| CREATOR | Klara Gawor, Sandra O Tomé, Rik Vandenberghe, Philip Van Damme, Mathieu Vandenbulcke, Markus Otto, Christine A F von Arnim, Estifanos Ghebremedhin, Alicja Ronisz, Simona Ospitalieri, Matthew Blaschko, Dietmar Rudolf Thal |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |