Effects of vitamin K supplementation on bone mineral density at different sites and bone metabolism in the middle-aged and elderly population
Chenqi Xie, Jianbao Gong, Chenglong Zheng, Junwei Zhang, Jie Gao, Chunyan Tian, Xiaofei Guo, Shiyou Dai, Tianlin Gao · 2024
Read Effects of vitamin K supplementation on bone mineral density at different sites and bone metabolism in the middle-aged and elderly population by Chenqi Xie, Jianbao Gong, Chenglong Zheng, Junwei Zhang, Jie Gao, Chunyan Tian, Xiaofei Guo, Shiyou Dai, Tianlin Gao (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11631259.txt.
Description
Chenqi Xie and co-authors pooled medical trials in 2024 to test what vitamin K supplements do to aging bones. Bone mineral density falls with age, and vitamin K is biologically plausible help, since it activates bone proteins, but trial results were scattered. Their systematic review and meta-analysis searched the major data stores for supplementation studies in middle-aged and older adults. It then pooled effects on density at several skeletal sites. It also pooled effects on a panel of blood markers of bone metabolism.
The clearest effect was anatomical: density increased greatly at the lumbar spine, while other sites showed no comparable gain. The protein chemistry moved as the process predicts. With more of the activated form of osteocalcin and less of its inactive form. And their ratio shifting greatly. Yet several standard turnover markers did not budge, and subgroup study located the spine benefit particularly in women.
Catalog record
| CREATOR | Chenqi Xie, Jianbao Gong, Chenglong Zheng, Junwei Zhang, Jie Gao, Chunyan Tian, Xiaofei Guo, Shiyou Dai, Tianlin Gao |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |