Identifying the molecular mechanism of blood stasis syndrome through the symptom phenotype–genotype association approach:
Minh Nhat Tran, Hyeong Joon Jun, Sanghun Lee · 2024
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Description
Minh Nhat Tran, Hyeong Joon Jun, and Sanghun Lee hunt for the molecular roots of blood stasis syndrome in this 2024 paper. In traditional medicine, the syndrome means sluggish blood flow. Its signs include fixed pain, a dark complexion, bleeding, and a rough pulse. Linking those signs to genes has been the hard part.
The team took a symptom-first route. They gathered the syndrome's symptoms from past studies, matched them to standard medical terms, and tied those terms to genes in a disease database. The result was a web of over thirteen hundred links between sixteen symptoms and more than nine hundred genes. Protein interaction maps then showed how those genes cluster into working groups. The web gives traditional diagnosis a testable molecular sketch, and points at hubs worth probing in the lab.
Catalog record
| CREATOR | Minh Nhat Tran, Hyeong Joon Jun, Sanghun Lee |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |