Revealing the core active pharmaceutical ingredients and targets of Jie-gu capsules for fracture treatment through network pharmacology and mendelian randomization
Ying Wang, Shuang Ding, Feng Gao, Yuyan Jia, Xukai Wang · 2024
Read Revealing the core active pharmaceutical ingredients and targets of Jie-gu capsules for fracture treatment through network pharmacology and mendelian randomization by Ying Wang, Shuang Ding, Feng Gao, Yuyan Jia, Xukai Wang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11630937.txt.
Description
Ying Wang and co-authors mine a classic Chinese bone healing capsule for its active core. The Jie-gu capsule is widely used for fractures in China, but its working parts were unclear. The team crossed herb compound lists with fracture patient gene data. Overlap genes were mapped into a protein web and tested for pathways.
Dozens of shared genes clustered around inflammation and a key growth pathway. Five compounds stood out as the likely core, all common plant chemicals. A genetics based check then pinned two target proteins. Docking models showed the core compounds grip those targets tightly. The authors offer the map as a base for lab proof.
Catalog record
| CREATOR | Ying Wang, Shuang Ding, Feng Gao, Yuyan Jia, Xukai Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |