Genomic landscape of malignant phyllodes tumors reveals multiple targetable opportunities
Laura H Rosenberger, Richard F Riedel, Emilia J Diego, Amanda L Nash, Juneko E Grilley-Olson, Natalie A Danziger, Ethan S Sokol, Jeffrey S Ross, Sarah L Sammons · 2024
Read Genomic landscape of malignant phyllodes tumors reveals multiple targetable opportunities by Laura H Rosenberger, Richard F Riedel, Emilia J Diego, Amanda L Nash, Juneko E Grilley-Olson, Natalie A Danziger, Ethan S Sokol, Jeffrey S Ross, Sarah L Sammons (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11630793.txt.
Description
Laura Rosenberger and co-authors profile the genomes of malignant phyllodes tumors in a 2024 study. These rare breast cancers have no known effective drug therapy, and spread brings a grim outlook. The team gathered sequenced cases from a certified clinical lab, where tumors were profiled on a panel of hundreds of genes, plus immune therapy biomarkers.
Of well over one hundred cases, most were local or locally recurrent and about a third had spread. Mutation burden was low on median, with few high burden cases, and about one in five tumors showed a key immune marker. The most altered gene was a promoter tied to cell immortality, altered in most cases. The landscape reveals several targetable openings.
Catalog record
| CREATOR | Laura H Rosenberger, Richard F Riedel, Emilia J Diego, Amanda L Nash, Juneko E Grilley-Olson, Natalie A Danziger, Ethan S Sokol, Jeffrey S Ross, Sarah L Sammons |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |