RNA splicing as a biomarker and phenotypic driver of meningioma DNA-methylation groups
Nathan K Leclair, Abrar Choudury, William C Chen, Stephen T Magill, Kathleen McCortney, Craig M Horbinski, Zhenhong Chen, Ezequiel Goldschmidt, Charlotte D Eaton, Ketan R Bulsara, Wenya Linda Bi, Akash J Patel, Felix Sahm, David Raleigh, Olga Anczukow · 2024
Read RNA splicing as a biomarker and phenotypic driver of meningioma DNA-methylation groups by Nathan K Leclair, Abrar Choudury, William C Chen, Stephen T Magill, Kathleen McCortney, Craig M Horbinski, Zhenhong Chen, Ezequiel Goldschmidt, Charlotte D Eaton, Ketan R Bulsara, Wenya Linda Bi, Akash J Patel, Felix Sahm, David Raleigh, Olga Anczukow (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11630566.txt.
Description
Nathan Leclair and co-authors show that RNA splicing both fingerprints and helps drive the main families of meningioma, in a 2024 study. Meningiomas are tumors of the brain's lining, now sorted by DNA methylation into three groups with different outlooks: merlin-intact, immune-enriched, and hypermitotic. What those chemical labels do to tumor behavior was the open question.
RNA sequencing of 486 tumors showed each methylation group splices its messages in a characteristic way, cutting and joining RNA pieces differently. Lab experiments in meningioma cell lines then tested whether splicing changes drive the group traits. A splicing readout could refine prognosis, and splicing machinery offers drug targets tuned to each family.
Catalog record
| CREATOR | Nathan K Leclair, Abrar Choudury, William C Chen, Stephen T Magill, Kathleen McCortney, Craig M Horbinski, Zhenhong Chen, Ezequiel Goldschmidt, Charlotte D Eaton, Ketan R Bulsara, Wenya Linda Bi, Akash J Patel, Felix Sahm, David Raleigh, Olga Anczukow |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |