Drug and biomarker tissue levels in a randomized presurgical trial on exemestane alternative schedules
Davide Serrano, Harriet Johansson, Bjørn-Erik Bertelsen, Sara Gandini, Gunnar Mellgren, Parijatham Thomas, Katherine D Crew, Nagi B Kumar, Debora Macis, Valentina Aristarco, Aliana Guerrieri-Gonzaga, Matteo Lazzeroni, Mauro D’Amico, Tania Buttiron-Webber, Irene Maria Briata, Stefano Spinaci, Viviana · 2024
Read Drug and biomarker tissue levels in a randomized presurgical trial on exemestane alternative schedules by Davide Serrano, Harriet Johansson, Bjørn-Erik Bertelsen, Sara Gandini, Gunnar Mellgren, Parijatham Thomas, Katherine D Crew, Nagi B Kumar, Debora Macis, Valentina Aristarco, Aliana Guerrieri-Gonzaga, Matteo Lazzeroni, Mauro D’Amico, Tania Buttiron-Webber, Irene Maria Briata, Stefano Spinaci, Viviana (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11630545.txt.
Description
Serrano and co-authors report drug and hormone levels inside breast tissue from a trial of lower exemestane schedules, in a study from 2024. Exemestane blocks estrogen production and is used against estrogen-driven breast cancer. Knowing the dose that works in the tissue itself could guide prevention use.
Women awaiting surgery were assigned for four to six weeks to a daily dose, a thrice-weekly dose, or a weekly dose. Tissue drug showed up only in the daily group, more in healthy tissue than in tumor. The key estrogen was nearly wiped out in healthy tissue on all three schedules. In tumor tissue, lower doses suppressed it less, in a dose-response pattern. The authors urge trials of low schedules for prevention.
Catalog record
| CREATOR | Davide Serrano, Harriet Johansson, Bjørn-Erik Bertelsen, Sara Gandini, Gunnar Mellgren, Parijatham Thomas, Katherine D Crew, Nagi B Kumar, Debora Macis, Valentina Aristarco, Aliana Guerrieri-Gonzaga, Matteo Lazzeroni, Mauro D’Amico, Tania Buttiron-Webber, Irene Maria Briata, Stefano Spinaci, Viviana |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 18 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |