Identification and characterization of human KALRN mRNA and Kalirin protein isoforms
Arne W Mould, David J Wright, Klaus D Bornemann, Bastian Hengerer, Rob Pinnock, Edward Drydale, James Bancroft, Nicola A L Hall, Annette von Delft, Paul E Brennan, Paul J Harrison, Wilfried Haerty, Elizabeth M Tunbridge · 2024
Read Identification and characterization of human KALRN mRNA and Kalirin protein isoforms by Arne W Mould, David J Wright, Klaus D Bornemann, Bastian Hengerer, Rob Pinnock, Edward Drydale, James Bancroft, Nicola A L Hall, Annette von Delft, Paul E Brennan, Paul J Harrison, Wilfried Haerty, Elizabeth M Tunbridge (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11630257.txt.
Description
Mould leads a large team cataloguing the transcript and protein forms of a brain gene called KALRN in a 2024 paper. The gene's product, kalirin, shapes neuron branches and spine growth. It is linked to several psychiatric disorders.
Full-length transcripts were read from adult frontal lobe, hippocampus, and aorta samples using long-read sequencing. Many new isoforms appeared, mostly shared between the two brain regions. Brain splicing favored one exon that adds a short protein segment near a key enzyme domain. Removing that segment barely changed enzyme activity but altered neurite outgrowth in cells. The authors say splicing may tune kalirin's role in the brain. The catalogue supports drug-target interest in the protein.
Catalog record
| CREATOR | Arne W Mould, David J Wright, Klaus D Bornemann, Bastian Hengerer, Rob Pinnock, Edward Drydale, James Bancroft, Nicola A L Hall, Annette von Delft, Paul E Brennan, Paul J Harrison, Wilfried Haerty, Elizabeth M Tunbridge |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |