Elevated α/β ratio after hypofractionated radiotherapy correlated with DNA damage repairment in an experimental model of prostate cancer
Ming Cui, Yuexian Li, Ji Liu, Deyu Sun · 2024
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Description
Ming Cui and co-authors probe why standard dose models misjudge large single radiation doses in prostate cancer, in a 2024 study. The linear-quadratic model converts fractionated treatment into an equivalent single dose, but the team suspected it overstates the effect of one big dose. They combined cell survival curves, DNA damage markers, and a mouse tumor model.
Converting split-dose results into a single dose indeed overstated the kill unless a larger alpha/beta ratio was used. A single high dose left more damage unrepaired after a day, while split doses showed steady repair activity. The authors explain that big doses turn some repairable damage into permanent damage, so extra fractions may be needed to match predictions.
Catalog record
| CREATOR | Ming Cui, Yuexian Li, Ji Liu, Deyu Sun |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |