PITX2 deficiency leads to atrial mitochondrial dysfunction
Jasmeet S Reyat, Laura C Sommerfeld, Molly O’Reilly, Victor Roth Cardoso, Ellen Thiemann, Abdullah O Khan, Christopher O’Shea, Sönke Harder, Christian Müller, Jonathan Barlow, Rachel J Stapley, Winnie Chua, S Nashitha Kabir, Olivia Grech, Oliver Hummel, Norbert Hübner, Stefan Kääb, Lluis Mont, Stéph · 2024
Read PITX2 deficiency leads to atrial mitochondrial dysfunction by Jasmeet S Reyat, Laura C Sommerfeld, Molly O’Reilly, Victor Roth Cardoso, Ellen Thiemann, Abdullah O Khan, Christopher O’Shea, Sönke Harder, Christian Müller, Jonathan Barlow, Rachel J Stapley, Winnie Chua, S Nashitha Kabir, Olivia Grech, Oliver Hummel, Norbert Hübner, Stefan Kääb, Lluis Mont, Stéph (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11630043.txt.
Description
Jasmeet Reyat and a large team of co-authors study how a lack of the PITX2 gene harms mitochondria in atrial heart cells. Their 2024 paper deals with atrial cardiomyopathy and atrial fibrillation, conditions linked to reduced PITX2 in the left atrium.
PITX2 is found only in left atrial cardiomyocytes in the adult heart, but its links to disease were not fully clear. The team made PITX2-deficient human atrial cells from induced pluripotent stem cells, with matched controls. The deficient cells showed shorter, disorganized sarcomeres and more mononucleation. Electron microscopy and other tests pointed to mitochondrial dysfunction as a core part of the defect.
Catalog record
| CREATOR | Jasmeet S Reyat, Laura C Sommerfeld, Molly O’Reilly, Victor Roth Cardoso, Ellen Thiemann, Abdullah O Khan, Christopher O’Shea, Sönke Harder, Christian Müller, Jonathan Barlow, Rachel J Stapley, Winnie Chua, S Nashitha Kabir, Olivia Grech, Oliver Hummel, Norbert Hübner, Stefan Kääb, Lluis Mont, Stéph |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |