Role of Autophagy in Type 2 Diabetes Mellitus: The Metabolic Clash
Yousef Abud Alanazi, Haydar M. Al‐kuraishy, Ali I. Al‐Gareeb, Athanasios Alexiou, Marios Papadakis, Mostafa M. Bahaa, Walaa A. Negm, Faisal Holil AlAnazi, Mohammed Alrouji, Gaber El‐Saber Batiha · 2024
Read Role of Autophagy in Type 2 Diabetes Mellitus: The Metabolic Clash by Yousef Abud Alanazi, Haydar M. Al‐kuraishy, Ali I. Al‐Gareeb, Athanasios Alexiou, Marios Papadakis, Mostafa M. Bahaa, Walaa A. Negm, Faisal Holil AlAnazi, Mohammed Alrouji, Gaber El‐Saber Batiha (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11629865.txt.
Description
Yousef Alanazi and nine co-authors review the double-edged role of cell self-eating in type 2 diabetes, in a 2024 paper. The disease grows from insulin resistance plus failing insulin cells. High sugar breeds stress that clogs those cells with worn parts. Self-eating, or autophagy, is the cleanup crew that recycles the clutter, and sugar stress switches it on.
In the insulin cells, the crew guards the machinery that senses sugar and ships insulin. Yet the same crew, over- or under-run, can hasten the cells' fall. The review walks through how cleanup touches each stage of the disease's clash between sugar load and cell health. It also weighs drug ideas that tune the crew up or down. The authors say timing and dose decide whether the crew saves or sinks the cell.
Catalog record
| CREATOR | Yousef Abud Alanazi, Haydar M. Al‐kuraishy, Ali I. Al‐Gareeb, Athanasios Alexiou, Marios Papadakis, Mostafa M. Bahaa, Walaa A. Negm, Faisal Holil AlAnazi, Mohammed Alrouji, Gaber El‐Saber Batiha |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |