Molecular targets and mechanisms of Sijunzi decoction in the treatment of Parkinson’s disease: evidence from network pharmacology, molecular docking, molecular dynamics simulation, and experimental validation
Yang Jiang, Wanfeng Wu, Le Xie, Yue Zhou, Kailin Yang, Dahua Wu, Wenfeng Xu, Rui Fang, Jinwen Ge · 2024
Read Molecular targets and mechanisms of Sijunzi decoction in the treatment of Parkinson’s disease: evidence from network pharmacology, molecular docking, molecular dynamics simulation, and experimental validation by Yang Jiang, Wanfeng Wu, Le Xie, Yue Zhou, Kailin Yang, Dahua Wu, Wenfeng Xu, Rui Fang, Jinwen Ge (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11629541.txt.
Description
Yang Jiang and eight co-authors published a pharmacology study in twenty twenty-four dissecting how Sijunzi decoction, a classic Chinese herbal formula, might act against Parkinson's disease. Rather than testing one molecule, the team mapped the whole formula computationally, then checked key predictions in cells.
Databases yielded one hundred eighty-eight active compounds and hundreds of targets shared with Parkinson's. Network analysis, docking, and molecular dynamics simulations ranked the likeliest interactions and pathways. Cell assays and protein blots then verified that predicted effects occur in living systems. The layered evidence chain, computation first and bench last, is the method's signature. The authors offer the target map as a hypothesis engine for future Parkinson's drug work.
Catalog record
| CREATOR | Yang Jiang, Wanfeng Wu, Le Xie, Yue Zhou, Kailin Yang, Dahua Wu, Wenfeng Xu, Rui Fang, Jinwen Ge |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |