Mitochondrial dysfunction of Astrocyte induces cell activation under high salt condition
Yuemin Qiu, Gengxin Lu, Shifeng Zhang, Li Minping, Xu Xue, Wu Junyu, Zhihui Zheng, Weiwei Qi, Junjie Guo, Dongxiao Zhou, Haiwei Huang, Zhezhi Deng · 2024
Read Mitochondrial dysfunction of Astrocyte induces cell activation under high salt condition by Yuemin Qiu, Gengxin Lu, Shifeng Zhang, Li Minping, Xu Xue, Wu Junyu, Zhihui Zheng, Weiwei Qi, Junjie Guo, Dongxiao Zhou, Haiwei Huang, Zhezhi Deng (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11629238.txt.
Description
Yuemin Qiu, Gengxin Lu, Shifeng Zhang, and a team of co-authors study what high salt does to astrocytes, the star-shaped support cells of the brain. Too much dietary salt can build up in brain tissue. Earlier work showed it switches these cells into an activated, inflamed state. Here the team looks inside the cell for the cause.
Gene readings showed that the cells' energy pathways slowed under high salt. Microscope images caught the mitochondria, the cells' power plants, swelling and losing their rod shape. Tests showed they breathed less and held less charge. A drug that acts on a mitochondrial protein partly restored the networks and calmed the activation. That points to a possible treatment angle for salt-related brain harm.
Catalog record
| CREATOR | Yuemin Qiu, Gengxin Lu, Shifeng Zhang, Li Minping, Xu Xue, Wu Junyu, Zhihui Zheng, Weiwei Qi, Junjie Guo, Dongxiao Zhou, Haiwei Huang, Zhezhi Deng |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |