Protective effect of xylosma congesta extract on renal injury in hyperuricemic rats
Jinjun He, Weiyi Tian, Yonghui Meng, An Yan, Xin Lai, Fei Wang, Bangwei Che · 2024
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Description
He and co-authors studied a plant extract that protects kidneys in rats with high uric acid, in a paper published in 2024. Excess uric acid can damage the kidneys over time. The team raised rats' uric acid for three weeks with a yeast-rich feed and injections of a chemical that blocks acid breakdown. They then treated the rats with a standard drug or with several doses of the plant extract. Blood and urine tests tracked uric acid and kidney function.
The extract lowered uric acid and eased the kidney injury. Tissue tests showed less programmed cell death in the kidney. The treatment also calmed an inflammation pathway and shifted kidney immune cells toward a healing type. The results support the plant as a candidate source for gentler uric acid control. Human use would need far more testing, the design of the study makes clear.
Catalog record
| CREATOR | Jinjun He, Weiyi Tian, Yonghui Meng, An Yan, Xin Lai, Fei Wang, Bangwei Che |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |